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ba0003OP25 | Pre-Clinical | ECTS2014

Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

Lamoureux Francois , Baud'huin Marc , Calleja Lidia Rodriguez , Jacques Camille , Redini Francoise , Lecanda Fernando , Bradner James E. , Heymann Dominique , Ory Benjamin

see PP103....

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ba0003pp103 | Cancer and bone: basic, translational and clinical | ECTS2014

Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

Lamoureux Francois , Baud'huin Marc , Calleja Lidia Rodriguez , Jacques Camille , Redini Francoise , Lecanda Fernando , Bradner James E. , Heymann Dominique , Ory Benjamin

The vicious cycle established between bone associated tumors and bone resorption is the central problem with therapeutic strategies against primary bone tumors and bone metastasis. The bromodomain and extra-terminal domain (BET) protein family is an important class of histone reading protein capable to recognize the N-acetylation of lysine residues on histone tails. BET bromain proteins have recently been described as regulators of MYC expression in various tumors....

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ba0005cabs.oc3.1 | Oral Communications | ECTS2016

Blockade of C5aR impairs tumor-induced osteoclastogenesis preventing bone metastasis colonization in lung cancer

Ajona Daniel , Zandueta Carolina , Corrales Leticia , Pajares Maria J. , Martinez-Terroba Elena , Perurena Naiara , Montuenga Luis M. , Pio Ruben , Lecanda Fernando

C5aR is a membrane-associated receptor for C5a, a potent immune mediator generated after complement activation. C5aR expressed in tumor infiltrating immune cells creates a favorable microenvironment for tumor progression. However, the expression of C5aR by cancer cells and its contribution to their malignant phenotype is poorly understood. Immunohistochemical analysis revealed that high levels of C5aR in human lung tumors were associated with poor survival (P=0.005) a...

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Bone Abstracts

Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

Blockade of C5aR impairs tumor-induced osteoclastogenesis preventing bone metastasis colonization in lung cancer

BiosciAbstracts